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Cryo-EM structure of substrate-bound human telomerase holoenzyme

Telomerase adds telomeric repeats to chromosome ends to balance incomplete replication. Telomerase regulation is implicated in cancer, aging and other human diseases, but progress towards telomerase clinical manipulation is hampered by the lack of structural data. Here we present the cryo-electron m...

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Detaylı Bibliyografya
Yayımlandı:Nature
Asıl Yazarlar: Nguyen, Thi Hoang Duong, Tam, Jane, Wu, Robert A., Greber, Basil J., Toso, Daniel, Nogales, Eva, Collins, Kathleen
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2018
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6223129/
https://ncbi.nlm.nih.gov/pubmed/29695869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-018-0062-x
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