Selective Janus Kinase Inhibition Preserves Interferon-Λ-mediated Antiviral Responses

Inflammatory diseases are frequently treated with Janus kinase (JAK) inhibitors to diminish cytokine signaling. These treatments can lead to inadvertent immune suppression and may increase the risk of viral infection. Tyrosine kinase 2 (TYK2) is a JAK family member required for efficient type I inte...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Sci Immunol
Main Authors: Schnepf, Daniel, Crotta, Stefania, Thamamongood, Thiprampai, Stanifer, Megan, Polcik, Laura, Ohnemus, Annette, Vier, Juliane, Jakob, Celia, Llorian, Miriam, Gad, Hans Henrik, Hartmann, Rune, Strobl, Birgit, Kirschnek, Susanne, Boulant, Steeve, Schwemmle, Martin, Wack, Andreas, Staeheli, Peter
Format: Artigo
Jezik:Inglês
Izdano: 2021
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7610871/
https://ncbi.nlm.nih.gov/pubmed/33990378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciimmunol.abd5318
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