Selective Janus Kinase Inhibition Preserves Interferon-Λ-mediated Antiviral Responses

Inflammatory diseases are frequently treated with Janus kinase (JAK) inhibitors to diminish cytokine signaling. These treatments can lead to inadvertent immune suppression and may increase the risk of viral infection. Tyrosine kinase 2 (TYK2) is a JAK family member required for efficient type I inte...

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Foilsithe in:Sci Immunol
Main Authors: Schnepf, Daniel, Crotta, Stefania, Thamamongood, Thiprampai, Stanifer, Megan, Polcik, Laura, Ohnemus, Annette, Vier, Juliane, Jakob, Celia, Llorian, Miriam, Gad, Hans Henrik, Hartmann, Rune, Strobl, Birgit, Kirschnek, Susanne, Boulant, Steeve, Schwemmle, Martin, Wack, Andreas, Staeheli, Peter
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2021
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7610871/
https://ncbi.nlm.nih.gov/pubmed/33990378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciimmunol.abd5318
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