Type I and III interferons disrupt lung epithelial repair during recovery from viral infection

Excessive cytokine signaling frequently exacerbates lung tissue damage during respiratory viral infection. Type I (IFN-α and IFN-β) and III (IFN-λ) interferons are host-produced antiviral cytokines. Prolonged IFN-α and IFN-β responses can lead to harmful proinflammatory effects, whereas IFN-λ mainly...

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Pubblicato in:Science
Autori principali: Major, Jack, Crotta, Stefania, Llorian, Miriam, McCabe, Teresa M., Gad, Hans Henrik, Priestnall, Simon L., Hartmann, Rune, Wack, Andreas
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Association for the Advancement of Science 2020
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Reports
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7292500/
https://ncbi.nlm.nih.gov/pubmed/32527928
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.abc2061
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