IFN-λ prevents influenza virus spread from the upper airways to the lungs and limits virus transmission

Host factors restricting the transmission of respiratory viruses are poorly characterized. We analyzed the contribution of type I and type III interferon (IFN) using a mouse model in which the virus is selectively administered to the upper airways, mimicking a natural respiratory virus infection. Mi...

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Bibliographic Details
Published in:eLife
Main Authors: Klinkhammer, Jonas, Schnepf, Daniel, Ye, Liang, Schwaderlapp, Marilena, Gad, Hans Henrik, Hartmann, Rune, Garcin, Dominique, Mahlakõiv, Tanel, Staeheli, Peter
Format: Artigo
Language:Inglês
Published: eLife Sciences Publications, Ltd 2018
Subjects:
Immunology and Inflammation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5953542/
https://ncbi.nlm.nih.gov/pubmed/29651984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.33354
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