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IFN-λ prevents influenza virus spread from the upper airways to the lungs and limits virus transmission

Host factors restricting the transmission of respiratory viruses are poorly characterized. We analyzed the contribution of type I and type III interferon (IFN) using a mouse model in which the virus is selectively administered to the upper airways, mimicking a natural respiratory virus infection. Mi...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Klinkhammer, Jonas, Schnepf, Daniel, Ye, Liang, Schwaderlapp, Marilena, Gad, Hans Henrik, Hartmann, Rune, Garcin, Dominique, Mahlakõiv, Tanel, Staeheli, Peter
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5953542/
https://ncbi.nlm.nih.gov/pubmed/29651984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.33354
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