Leukocyte-Derived IFN-α/β and Epithelial IFN-λ Constitute a Compartmentalized Mucosal Defense System that Restricts Enteric Virus Infections

Epithelial cells are a major port of entry for many viruses, but the molecular networks which protect barrier surfaces against viral infections are incompletely understood. Viral infections induce simultaneous production of type I (IFN-α/β) and type III (IFN-λ) interferons. All nucleated cells are b...

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Publicat a:PLoS Pathog
Autors principals: Mahlakõiv, Tanel, Hernandez, Pedro, Gronke, Konrad, Diefenbach, Andreas, Staeheli, Peter
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2015
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4388470/
https://ncbi.nlm.nih.gov/pubmed/25849543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1004782
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