IFN-λ determines the intestinal epithelial antiviral host defense

Type I and type III IFNs bind to different cell-surface receptors but induce identical signal transduction pathways, leading to the expression of antiviral host effector molecules. Despite the fact that type III IFN (IFN-λ) has been shown to predominantly act on mucosal organs, in vivo infection stu...

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Hlavní autoři: Pott, Johanna, Mahlakõiv, Tanel, Mordstein, Markus, Duerr, Claudia U., Michiels, Thomas, Stockinger, Silvia, Staeheli, Peter, Hornef, Mathias W.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2011
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3093475/
https://ncbi.nlm.nih.gov/pubmed/21518880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1100552108
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