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Proton-sensing G protein-coupled receptors: detectors of tumor acidosis and candidate drug targets
Cells in tumor microenvironments (TMEs) use several mechanisms to sense their low pH (<7.0), including via proton-sensing G protein-coupled receptors (psGPCRs): GPR4, GPR65/TDAG8, GPR68/OGR1 and GPR132/G2A. Numerous cancers have increased expression of psGPCRs. The psGPCRs may contribute to featu...
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| 出版年: | Future Med Chem |
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| 主要な著者: | , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Newlands Press Ltd
2020
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7607387/ https://ncbi.nlm.nih.gov/pubmed/32116003 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4155/fmc-2019-0357 |
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