GPR68, a proton-sensing GPCR, mediates interaction of cancer-associated fibroblasts and cancer cells

The microenvironment of pancreatic ductal adenocarcinoma (PDAC) is characterized by a dense fibrotic stroma (desmoplasia) generated by pancreatic cancer–associated fibroblasts (CAFs) derived from pancreatic stellate cells (PSCs) and pancreatic fibroblasts (PFs). Using an unbiased GPCRomic array appr...

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Detalhes bibliográficos
Publicado no:FASEB J
Main Authors: Wiley, Shu Z., Sriram, Krishna, Liang, Wenjing, Chang, Sarah E., French, Randall, McCann, Thalia, Sicklick, Jason, Nishihara, Hiroshi, Lowy, Andrew M., Insel, Paul A.
Formato: Artigo
Idioma:Inglês
Publicado em: Federation of American Societies for Experimental Biology 2018
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5892729/
https://ncbi.nlm.nih.gov/pubmed/29092903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201700834R
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