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Proton-sensing G protein-coupled receptors: detectors of tumor acidosis and candidate drug targets

Cells in tumor microenvironments (TMEs) use several mechanisms to sense their low pH (<7.0), including via proton-sensing G protein-coupled receptors (psGPCRs): GPR4, GPR65/TDAG8, GPR68/OGR1 and GPR132/G2A. Numerous cancers have increased expression of psGPCRs. The psGPCRs may contribute to featu...

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Detalhes bibliográficos
Publicado no:Future Med Chem
Main Authors: Insel, Paul A, Sriram, Krishna, Salmerón, Cristina, Wiley, Shu Z
Formato: Artigo
Idioma:Inglês
Publicado em: Newlands Press Ltd 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7607387/
https://ncbi.nlm.nih.gov/pubmed/32116003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4155/fmc-2019-0357
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