Discovery of the first potent proteolysis targeting chimera (PROTAC) degrader of indoleamine 2,3-dioxygenase 1

Cancer immunotherapy is revolutionizing oncology and has emerged as a promising strategy for the treatment of multiple cancers. Indoleamine 2,3-dioxygenase 1 (IDO1), an immune checkpoint, plays an important role in tumor immune escape through the regulation of multiple immune cells and has been rega...

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Dettagli Bibliografici
Pubblicato in:Acta Pharm Sin B
Autori principali: Hu, Mingxing, Zhou, Weilin, Wang, Yijie, Yao, Dongping, Ye, Tinghong, Yao, Yuqin, Chen, Bin, Liu, Gongping, Yang, Xifei, Wang, Wei, Xie, Yongmei
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2020
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7606109/
https://ncbi.nlm.nih.gov/pubmed/33163345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.apsb.2020.02.010
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