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Fused Heterocyclic Compounds as Potent Indoleamine-2,3-dioxygenase 1 Inhibitors

[Image: see text] Uncontrolled metabolism of l-tryptophan (l-Trp) in the immune system has been recognized as a critical cellular process in immune tolerance. Indoleamine 2,3-dioxygenase 1 (IDO1) enzyme plays an important role in the metabolism of a local l-Trp through the kynurenine pathway in the...

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Detalles Bibliográficos
Publicado en:ACS Med Chem Lett
Main Authors: Panda, Subhankar, Roy, Ashalata, Deka, Suman Jyoti, Trivedi, Vishal, Manna, Debasis
Formato: Artigo
Idioma:Inglês
Publicado: American Chemical Society 2016
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5150662/
https://ncbi.nlm.nih.gov/pubmed/27994758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.6b00359
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