Activation of the CARD8 Inflammasome Requires a Disordered Region

Several cytosolic pattern-recognition receptors (PRRs) form multiprotein complexes called canonical inflammasomes in response to intracellular danger signals. Canonical inflammasomes recruit and activate caspase-1 (CASP1), which in turn cleaves and activates inflammatory cytokines and gasdermin D (G...

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Bibliografiske detaljer
Udgivet i:Cell Rep
Main Authors: Chui, Ashley J., Griswold, Andrew R., Taabazuing, Cornelius Y., Orth, Elizabeth L., Gai, Kuo, Rao, Sahana D., Ball, Daniel P., Hsiao, Jeffrey C., Bachovchin, Daniel A.
Format: Artigo
Sprog:Inglês
Udgivet: 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7594595/
https://ncbi.nlm.nih.gov/pubmed/33053349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2020.108264
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