Hematopoietic stem cell function in β-thalassemia is impaired and is rescued by targeting the bone marrow niche

Hematopoietic stem cells (HSCs) are regulated by signals from the bone marrow (BM) niche that tune hematopoiesis at steady state and in hematologic disorders. To understand HSC-niche interactions in altered nonmalignant homeostasis, we selected β-thalassemia, a hemoglobin disorder, as a paradigm. In...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:Blood
Main Authors: Aprile, Annamaria, Gulino, Alessandro, Storto, Mariangela, Villa, Isabella, Beretta, Stefano, Merelli, Ivan, Rubinacci, Alessandro, Ponzoni, Maurilio, Marktel, Sarah, Tripodo, Claudio, Lidonnici, Maria Rosa, Ferrari, Giuliana
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2020
Fag:
Red Cells, Iron, and Erythropoiesis
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7547533/
https://ncbi.nlm.nih.gov/pubmed/32344432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2019002721
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker