KLF1 mutations are relatively more common in a thalassemia endemic region and ameliorate the severity of β-thalassemia

Mutations in human Krüppel-like factor 1 (KLF1) have recently been reported to be responsible for increased fetal hemoglobin (HbF) and hemoglobin A(2) (HbA(2)). Because increased HbF and HbA(2) levels are important features of β-thalassemia, we examined whether there is any relationship between KLF1...

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Detalhes bibliográficos
Principais autores: Liu, Dun, Zhang, Xinhua, Yu, Lihua, Cai, Ren, Ma, Xiaoxia, Zheng, Chengguang, Zhou, Yuqiu, Liu, Qiji, Wei, Xiaofeng, Lin, Li, Yan, Tizhen, Huang, Jiwei, Mohandas, Narla, An, Xiuli, Xu, Xiangmin
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2014
Assuntos:
Red Cells, Iron, and Erythropoiesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4118488/
https://ncbi.nlm.nih.gov/pubmed/24829204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-03-561779
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