Correcting β-thalassemia by combined therapies that restrict iron and modulate erythropoietin activity

β-Thalassemia intermedia is a disorder characterized by ineffective erythropoiesis (IE), anemia, splenomegaly, and systemic iron overload. Novel approaches are being explored based on the modulation of pathways that reduce iron absorption (ie, using hepcidin activators like Tmprss6-antisense oligonu...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Casu, Carla, Pettinato, Mariateresa, Liu, Alison, Aghajan, Mariam, Lo Presti, Vania, Lidonnici, Maria Rosa, Munoz, Kevin A., O’Hara, Emir, Olivari, Violante, Di Modica, Simona Maria, Booten, Sheri, Guo, Shuling, Neil, Garry, Miari, Reem, Shapir, Nir, Zafir-Lavie, Inbal, Domev, Hagit, Ferrari, Giuliana, Sitara, Despina, Nai, Antonella, Rivella, Stefano
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2020
Assuntos:
Red Cells, Iron, and Erythropoiesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8209564/
https://ncbi.nlm.nih.gov/pubmed/32556142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2019004719
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