Correcting β-thalassemia by combined therapies that restrict iron and modulate erythropoietin activity

β-Thalassemia intermedia is a disorder characterized by ineffective erythropoiesis (IE), anemia, splenomegaly, and systemic iron overload. Novel approaches are being explored based on the modulation of pathways that reduce iron absorption (ie, using hepcidin activators like Tmprss6-antisense oligonu...

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Bibliografiset tiedot
Julkaisussa:Blood
Päätekijät: Casu, Carla, Pettinato, Mariateresa, Liu, Alison, Aghajan, Mariam, Lo Presti, Vania, Lidonnici, Maria Rosa, Munoz, Kevin A., O’Hara, Emir, Olivari, Violante, Di Modica, Simona Maria, Booten, Sheri, Guo, Shuling, Neil, Garry, Miari, Reem, Shapir, Nir, Zafir-Lavie, Inbal, Domev, Hagit, Ferrari, Giuliana, Sitara, Despina, Nai, Antonella, Rivella, Stefano
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society of Hematology 2020
Aiheet:
Red Cells, Iron, and Erythropoiesis
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC8209564/
https://ncbi.nlm.nih.gov/pubmed/32556142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2019004719
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