Hepcidin is suppressed by erythropoiesis in hemoglobin E β-thalassemia and β-thalassemia trait

Hemoglobin E (HbE) β-thalassemia is the most common severe thalassemia syndrome across Asia, and millions of people are carriers. Clinical heterogeneity in HbE β-thalassemia is incompletely explained by genotype, and the interaction of phenotypic variation with hepcidin is unknown. The effect of tha...

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Bibliographic Details
Published in:Blood
Main Authors: Jones, Emma, Pasricha, Sant-Rayn, Allen, Angela, Evans, Patricia, Fisher, Chris A., Wray, Katherine, Premawardhena, Anuja, Bandara, Dyananda, Perera, Ashok, Webster, Craig, Sturges, Pamela, Olivieri, Nancy F., St. Pierre, Timothy, Armitage, Andrew E., Porter, John B., Weatherall, David J., Drakesmith, Hal
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2015
Subjects:
Red Cells, Iron, and Erythropoiesis
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4321326/
https://ncbi.nlm.nih.gov/pubmed/25519750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-10-606491
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