Hepcidin is suppressed by erythropoiesis in hemoglobin E β-thalassemia and β-thalassemia trait

Hemoglobin E (HbE) β-thalassemia is the most common severe thalassemia syndrome across Asia, and millions of people are carriers. Clinical heterogeneity in HbE β-thalassemia is incompletely explained by genotype, and the interaction of phenotypic variation with hepcidin is unknown. The effect of tha...

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Publicat a:Blood
Autors principals: Jones, Emma, Pasricha, Sant-Rayn, Allen, Angela, Evans, Patricia, Fisher, Chris A., Wray, Katherine, Premawardhena, Anuja, Bandara, Dyananda, Perera, Ashok, Webster, Craig, Sturges, Pamela, Olivieri, Nancy F., St. Pierre, Timothy, Armitage, Andrew E., Porter, John B., Weatherall, David J., Drakesmith, Hal
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2015
Matèries:
Red Cells, Iron, and Erythropoiesis
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4321326/
https://ncbi.nlm.nih.gov/pubmed/25519750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-10-606491
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