Hepcidin is suppressed by erythropoiesis in hemoglobin E β-thalassemia and β-thalassemia trait

Hemoglobin E (HbE) β-thalassemia is the most common severe thalassemia syndrome across Asia, and millions of people are carriers. Clinical heterogeneity in HbE β-thalassemia is incompletely explained by genotype, and the interaction of phenotypic variation with hepcidin is unknown. The effect of tha...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Jones, Emma, Pasricha, Sant-Rayn, Allen, Angela, Evans, Patricia, Fisher, Chris A., Wray, Katherine, Premawardhena, Anuja, Bandara, Dyananda, Perera, Ashok, Webster, Craig, Sturges, Pamela, Olivieri, Nancy F., St. Pierre, Timothy, Armitage, Andrew E., Porter, John B., Weatherall, David J., Drakesmith, Hal
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2015
Assuntos:
Red Cells, Iron, and Erythropoiesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4321326/
https://ncbi.nlm.nih.gov/pubmed/25519750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-10-606491
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