Hematopoietic stem cell function in β-thalassemia is impaired and is rescued by targeting the bone marrow niche

Hematopoietic stem cells (HSCs) are regulated by signals from the bone marrow (BM) niche that tune hematopoiesis at steady state and in hematologic disorders. To understand HSC-niche interactions in altered nonmalignant homeostasis, we selected β-thalassemia, a hemoglobin disorder, as a paradigm. In...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Aprile, Annamaria, Gulino, Alessandro, Storto, Mariangela, Villa, Isabella, Beretta, Stefano, Merelli, Ivan, Rubinacci, Alessandro, Ponzoni, Maurilio, Marktel, Sarah, Tripodo, Claudio, Lidonnici, Maria Rosa, Ferrari, Giuliana
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2020
Assuntos:
Red Cells, Iron, and Erythropoiesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7547533/
https://ncbi.nlm.nih.gov/pubmed/32344432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2019002721
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