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Thermostability of a recombinant G protein-coupled receptor expressed at high level in mammalian cell culture
Rational design of pharmaceutical drugs targeting integral membrane G protein-coupled receptors (GPCR) requires thorough understanding of ligand binding and mechanism of activation through high resolution structural studies of purified proteins. Due to inherent conformational flexibility of GPCR, st...
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| Publicado no: | Sci Rep |
|---|---|
| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7546613/ https://ncbi.nlm.nih.gov/pubmed/33033368 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-73813-7 |
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