Structural insights into pseudokinase domains of receptor tyrosine kinases

Despite their apparent lack of catalytic activity, pseudokinases are essential signaling molecules. Here, we describe the structural and dynamic properties of pseudokinase domains from the Wnt-binding receptor tyrosine kinases (PTK7, ROR1, ROR2, RYK), which play important roles in development. We de...

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Detalhes bibliográficos
Publicado no:Mol Cell
Main Authors: Sheetz, Joshua B., Mathea, Sebastian, Karvonen, Hanna, Malhotra, Ketan, Chatterjee, Deep, Niininen, Wilhelmiina, Perttilä, Robert, Preuss, Franziska, Suresh, Krishna, Stayrook, Steven E., Tsutsui, Yuko, Radhakrishnan, Ravi, Ungureanu, Daniela, Knapp, Stefan, Lemmon, Mark A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7543951/
https://ncbi.nlm.nih.gov/pubmed/32619402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2020.06.018
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