Structural insights into pseudokinase domains of receptor tyrosine kinases

Despite their apparent lack of catalytic activity, pseudokinases are essential signaling molecules. Here, we describe the structural and dynamic properties of pseudokinase domains from the Wnt-binding receptor tyrosine kinases (PTK7, ROR1, ROR2, RYK), which play important roles in development. We de...

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Bibliographic Details
Published in:Mol Cell
Main Authors: Sheetz, Joshua B., Mathea, Sebastian, Karvonen, Hanna, Malhotra, Ketan, Chatterjee, Deep, Niininen, Wilhelmiina, Perttilä, Robert, Preuss, Franziska, Suresh, Krishna, Stayrook, Steven E., Tsutsui, Yuko, Radhakrishnan, Ravi, Ungureanu, Daniela, Knapp, Stefan, Lemmon, Mark A.
Format: Artigo
Language:Inglês
Published: 2020
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7543951/
https://ncbi.nlm.nih.gov/pubmed/32619402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2020.06.018
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