Structural insights into pseudokinase domains of receptor tyrosine kinases

Despite their apparent lack of catalytic activity, pseudokinases are essential signaling molecules. Here, we describe the structural and dynamic properties of pseudokinase domains from the Wnt-binding receptor tyrosine kinases (PTK7, ROR1, ROR2, RYK), which play important roles in development. We de...

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Détails bibliographiques
Publié dans:Mol Cell
Auteurs principaux: Sheetz, Joshua B., Mathea, Sebastian, Karvonen, Hanna, Malhotra, Ketan, Chatterjee, Deep, Niininen, Wilhelmiina, Perttilä, Robert, Preuss, Franziska, Suresh, Krishna, Stayrook, Steven E., Tsutsui, Yuko, Radhakrishnan, Ravi, Ungureanu, Daniela, Knapp, Stefan, Lemmon, Mark A.
Format: Artigo
Langue:Inglês
Publié: 2020
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7543951/
https://ncbi.nlm.nih.gov/pubmed/32619402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2020.06.018
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