Structural basis for substrate recognition and chemical inhibition of oncogenic MAGE ubiquitin ligases

Testis-restricted melanoma antigen (MAGE) proteins are frequently hijacked in cancer and play a critical role in tumorigenesis. MAGEs assemble with E3 ubiquitin ligases and function as substrate adaptors that direct the ubiquitination of novel targets, including key tumor suppressors. However, how M...

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Publicat a:Nat Commun
Autors principals: Yang, Seung Wook, Huang, Xin, Lin, Wenwei, Min, Jaeki, Miller, Darcie J., Mayasundari, Anand, Rodrigues, Patrick, Griffith, Elizabeth C., Gee, Clifford T., Li, Lei, Li, Wei, Lee, Richard E., Rankovic, Zoran, Chen, Taosheng, Potts, Patrick Ryan
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7529893/
https://ncbi.nlm.nih.gov/pubmed/33004795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-18708-x
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