A conditional mouse expressing an activating mutation in NRF2 displays hyperplasia of the upper gastrointestinal tract and decreased white adipose tissue

Activation of the nuclear factor (erythroid-derived 2)-like 2 (NFE2L2 or NRF2) transcription factor is a critical and evolutionarily conserved cellular response to oxidative stress, metabolic stress, and xenobiotic insult. Deficiency of NRF2 results in hypersensitivity to a variety of stressors, whe...

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Publicado no:J Pathol
Main Authors: Bowman, Brittany M., Montgomery, Stephanie A., Schrank, Travis P., Simon, Jeremy M., Ptacek, Travis S., Tamir, Tigist Y., Muvlaney, Kathleen M., Weir, Seth J., Nguyen, Tuong T., Murphy, Ryan M., Makowski, Liza, Hayes, D. Neil., Chen, Xiaoxin L., Randell, Scott H., Weissman, Bernard E., Major, Michael B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7511428/
https://ncbi.nlm.nih.gov/pubmed/32619021
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/path.5504
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