Gain-of-function genetic screen of the kinome reveals BRSK2 as an inhibitor of the NRF2 transcription factor

Nuclear factor erythroid 2-related factor 2 (NFE2L2, also known as NRF2) is a transcription factor and master regulator of cellular antioxidant response. Aberrantly high NRF2-dependent transcription is recurrent in human cancer, but conversely NRF2 activity diminishes with age and in neurodegenerati...

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Bibliographic Details
Published in:J Cell Sci
Main Authors: Tamir, Tigist Y., Bowman, Brittany M., Agajanian, Megan J., Goldfarb, Dennis, Schrank, Travis P., Stohrer, Trent, Hale, Andrew E., Siesser, Priscila F., Weir, Seth J., Murphy, Ryan M., LaPak, Kyle M., Weissman, Bernard E., Moorman, Nathaniel J., Major, M. Ben
Format: Artigo
Language:Inglês
Published: The Company of Biologists Ltd 2020
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7375482/
https://ncbi.nlm.nih.gov/pubmed/32546533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.241356
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