p62-Dependent Phase Separation of Patient-Derived KEAP1 Mutations and NRF2

Cancer-derived loss-of-function mutations in the KEAP1 tumor suppressor gene stabilize the NRF2 transcription factor, resulting in a prosurvival gene expression program that alters cellular metabolism and neutralizes oxidative stress. In a recent genotype-phenotype study, we classified 40% of KEAP1...

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Pubblicato in:Mol Cell Biol
Autori principali: Cloer, E. W., Siesser, P. F., Cousins, E. M., Goldfarb, D., Mowrey, D. D., Harrison, J. S., Weir, S. J., Dokholyan, N. V., Major, M. B.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2018
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6206457/
https://ncbi.nlm.nih.gov/pubmed/30126895
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00644-17
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