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p62-Dependent Phase Separation of Patient-Derived KEAP1 Mutations and NRF2
Cancer-derived loss-of-function mutations in the KEAP1 tumor suppressor gene stabilize the NRF2 transcription factor, resulting in a prosurvival gene expression program that alters cellular metabolism and neutralizes oxidative stress. In a recent genotype-phenotype study, we classified 40% of KEAP1...
Tallennettuna:
| Julkaisussa: | Mol Cell Biol |
|---|---|
| Päätekijät: | , , , , , , , , |
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
American Society for Microbiology
2018
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6206457/ https://ncbi.nlm.nih.gov/pubmed/30126895 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00644-17 |
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