Identification and Characterization of MCM3 as a Kelch-like ECH-associated Protein 1 (KEAP1) Substrate

KEAP1 is a substrate adaptor protein for a CUL3-based E3 ubiquitin ligase. Ubiquitylation and degradation of the antioxidant transcription factor NRF2 is considered the primary function of KEAP1; however, few other KEAP1 substrates have been identified. Because KEAP1 is altered in a number of human...

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Veröffentlicht in:J Biol Chem
Hauptverfasser: Mulvaney, Kathleen M., Matson, Jacob P., Siesser, Priscila F., Tamir, Tigist Y., Goldfarb, Dennis, Jacobs, Timothy M., Cloer, Erica W., Harrison, Joseph S., Vaziri, Cyrus, Cook, Jeanette G., Major, Michael B.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2016
Schlagworte:
Signal Transduction
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5095425/
https://ncbi.nlm.nih.gov/pubmed/27621311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.729418
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