Identification and Characterization of MCM3 as a Kelch-like ECH-associated Protein 1 (KEAP1) Substrate

KEAP1 is a substrate adaptor protein for a CUL3-based E3 ubiquitin ligase. Ubiquitylation and degradation of the antioxidant transcription factor NRF2 is considered the primary function of KEAP1; however, few other KEAP1 substrates have been identified. Because KEAP1 is altered in a number of human...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:J Biol Chem
Autori principali: Mulvaney, Kathleen M., Matson, Jacob P., Siesser, Priscila F., Tamir, Tigist Y., Goldfarb, Dennis, Jacobs, Timothy M., Cloer, Erica W., Harrison, Joseph S., Vaziri, Cyrus, Cook, Jeanette G., Major, Michael B.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2016
Soggetti:
Signal Transduction
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5095425/
https://ncbi.nlm.nih.gov/pubmed/27621311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.729418
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi