Proteomic analysis of ubiquitin ligase KEAP1 reveals associated proteins that inhibit NRF2 ubiquitination

Somatic mutations in the KEAP1 ubiquitin ligase or its substrate NRF2 (NFE2L2) commonly occur in human cancer, resulting in constitutive NRF2-mediated transcription of cytoprotective genes. However, many tumors display high NRF2 activity in the absence of mutation, supporting the hypothesis that alt...

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Autores principales: Hast, Bridgid E., Goldfarb, Dennis, Mulvaney, Kathleen M., Hast, Michael A., Siesser, Priscila F., Yan, Feng, Hayes, D. Neil, Major, Michael B.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2013
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3618590/
https://ncbi.nlm.nih.gov/pubmed/23382044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-12-4400
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