Proteomic analysis of ubiquitin ligase KEAP1 reveals associated proteins that inhibit NRF2 ubiquitination

Somatic mutations in the KEAP1 ubiquitin ligase or its substrate NRF2 (NFE2L2) commonly occur in human cancer, resulting in constitutive NRF2-mediated transcription of cytoprotective genes. However, many tumors display high NRF2 activity in the absence of mutation, supporting the hypothesis that alt...

Cur síos iomlán

Na minha lista:
Sonraí Bibleagrafaíochta
Main Authors: Hast, Bridgid E., Goldfarb, Dennis, Mulvaney, Kathleen M., Hast, Michael A., Siesser, Priscila F., Yan, Feng, Hayes, D. Neil, Major, Michael B.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2013
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3618590/
https://ncbi.nlm.nih.gov/pubmed/23382044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-12-4400
Clibeanna: Cuir Clib Leis
Gan Chlibeanna, Bí ar an gcéad duine leis an taifead seo a chlibeáil!

Míreanna Comhchosúla