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Activation of the Keap1/Nrf2 pathway for neuroprotection by electrophillic phase II inducers

Electrophilic neurite outgrowth-promoting prostaglandin (NEPP) compounds protect neurons from oxidative insults. At least part of the neuroprotective action of NEPPs lies in induction of hemeoxygenase-1 (HO-1), which, along with other phase II enzymes, serve as a defense system against oxidative str...

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Autors principals: Satoh, T., Okamoto, S.-i., Cui, J., Watanabe, Y., Furuta, K., Suzuki, M., Tohyama, K., Lipton, S. A.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2006
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1334635/
https://ncbi.nlm.nih.gov/pubmed/16407140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0505723102
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