Dual Neuroprotective Pathways of a Pro-Electrophilic Compound via HSF-1-activated Heat Shock Proteins and Nrf2-activated Phase 2 Antioxidant Response Enzymes

Activation of the Keap1/Nrf2 pathway and consequent induction of phase 2 antioxidant enzymes is known to afford neuroprotection. Here, we present a series of novel electrophilic compounds that protect neurons via this pathway. Natural products, such as carnosic acid (CA), are present in high amounts...

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Bibliografiske detaljer
Udgivet i:J Neurochem
Main Authors: Satoh, Takumi, Rezaie, Tayebeh, Seki, Masaaki, Sunico, Carmen R., Tabuchi, Takahito, Kitagawa, Tomomi, Yanagitai, Mika, Senzaki, Mutsumi, Kosegawa, Chihiro, Taira, Hideharu, McKercher, Scott R., Hoffman, Jennifer K., Roth, Gregory P., Lipton, Stuart A.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4580255/
https://ncbi.nlm.nih.gov/pubmed/21883218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1471-4159.2011.07449.x
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