Nrf2 and HSF-1 Pathway Activation via Hydroquinone-Based Proelectrophilic Small Molecules Is Regulated by Electrochemical Oxidation Potential

Activation of the Kelch-like ECH-associated protein 1/nuclear factor (erythroid-derived 2)-like 2 and heat-shock protein 90/heat-shock factor-1 signal-transduction pathways plays a central role in combatting cellular oxidative damage and related endoplasmic reticulum stress. Electrophilic compounds...

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Publicat a:ASN Neuro
Autors principals: Satoh, Takumi, Stalder, Romain, McKercher, Scott R., Williamson, Robert E., Roth, Gregory P., Lipton, Stuart A.
Format: Artigo
Idioma:Inglês
Publicat: SAGE Publications 2015
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4550314/
https://ncbi.nlm.nih.gov/pubmed/26243592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1759091415593294
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