Gain-of-function genetic screen of the kinome reveals BRSK2 as an inhibitor of the NRF2 transcription factor

Nuclear factor erythroid 2-related factor 2 (NFE2L2, also known as NRF2) is a transcription factor and master regulator of cellular antioxidant response. Aberrantly high NRF2-dependent transcription is recurrent in human cancer, but conversely NRF2 activity diminishes with age and in neurodegenerati...

Descripción completa

Guardado en:
Detalles Bibliográficos
Publicado en:J Cell Sci
Autores principales: Tamir, Tigist Y., Bowman, Brittany M., Agajanian, Megan J., Goldfarb, Dennis, Schrank, Travis P., Stohrer, Trent, Hale, Andrew E., Siesser, Priscila F., Weir, Seth J., Murphy, Ryan M., LaPak, Kyle M., Weissman, Bernard E., Moorman, Nathaniel J., Major, M. Ben
Formato: Artigo
Lenguaje:Inglês
Publicado: The Company of Biologists Ltd 2020
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7375482/
https://ncbi.nlm.nih.gov/pubmed/32546533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.241356
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares