Gain-of-function genetic screen of the kinome reveals BRSK2 as an inhibitor of the NRF2 transcription factor

Nuclear factor erythroid 2-related factor 2 (NFE2L2, also known as NRF2) is a transcription factor and master regulator of cellular antioxidant response. Aberrantly high NRF2-dependent transcription is recurrent in human cancer, but conversely NRF2 activity diminishes with age and in neurodegenerati...

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Vydáno v:J Cell Sci
Hlavní autoři: Tamir, Tigist Y., Bowman, Brittany M., Agajanian, Megan J., Goldfarb, Dennis, Schrank, Travis P., Stohrer, Trent, Hale, Andrew E., Siesser, Priscila F., Weir, Seth J., Murphy, Ryan M., LaPak, Kyle M., Weissman, Bernard E., Moorman, Nathaniel J., Major, M. Ben
Médium: Artigo
Jazyk:Inglês
Vydáno: The Company of Biologists Ltd 2020
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7375482/
https://ncbi.nlm.nih.gov/pubmed/32546533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.241356
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