A conditional mouse expressing an activating mutation in NRF2 displays hyperplasia of the upper gastrointestinal tract and decreased white adipose tissue

Activation of the nuclear factor (erythroid-derived 2)-like 2 (NFE2L2 or NRF2) transcription factor is a critical and evolutionarily conserved cellular response to oxidative stress, metabolic stress, and xenobiotic insult. Deficiency of NRF2 results in hypersensitivity to a variety of stressors, whe...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Pathol
Prif Awduron: Bowman, Brittany M., Montgomery, Stephanie A., Schrank, Travis P., Simon, Jeremy M., Ptacek, Travis S., Tamir, Tigist Y., Muvlaney, Kathleen M., Weir, Seth J., Nguyen, Tuong T., Murphy, Ryan M., Makowski, Liza, Hayes, D. Neil., Chen, Xiaoxin L., Randell, Scott H., Weissman, Bernard E., Major, Michael B.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2020
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7511428/
https://ncbi.nlm.nih.gov/pubmed/32619021
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/path.5504
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