Loss of SWI/SNF chromatin remodeling alters NRF2 signaling in non-small cell lung carcinoma

The NF-E2-related factor 2 (referred to as NRF2) transcription factor binds antioxidant responsive elements within the promoters of cytoprotective genes to induce their expression. Next-generation sequencing studies in lung cancer have shown a significant number of activating mutations within the NR...

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Udgivet i:Mol Cancer Res
Main Authors: Song, Shujie, Nguyen, Vinh, Schrank, Travis, Mulvaney, Kathleen, Walter, Vonn, Wei, Darmood, Orvis, Tess, Desai, Nisarg, Zhang, Jiren, Hayes, D. Neil, Zheng, Yanfang, Major, Michael B., Weissman, Bernard E.
Format: Artigo
Sprog:Inglês
Udgivet: 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7718321/
https://ncbi.nlm.nih.gov/pubmed/32855269
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-20-0082
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