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Engineering a genetically encoded competitive inhibitor of the KEAP1–NRF2 interaction via structure-based design and phage display
In its basal state, KEAP1 binds the transcription factor NRF2 (K(d) = 5 nM) and promotes its degradation by ubiquitylation. Changes in the redox environment lead to modification of key cysteines within KEAP1, resulting in NRF2 protein accumulation and the transcription of genes important for restori...
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| Publicado no: | Protein Eng Des Sel |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4678006/ https://ncbi.nlm.nih.gov/pubmed/26489878 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/protein/gzv055 |
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