Engineering a genetically encoded competitive inhibitor of the KEAP1–NRF2 interaction via structure-based design and phage display

In its basal state, KEAP1 binds the transcription factor NRF2 (K(d) = 5 nM) and promotes its degradation by ubiquitylation. Changes in the redox environment lead to modification of key cysteines within KEAP1, resulting in NRF2 protein accumulation and the transcription of genes important for restori...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Protein Eng Des Sel
Egile Nagusiak: Guntas, Gurkan, Lewis, Steven M., Mulvaney, Kathleen M., Cloer, Erica W., Tripathy, Ashutosh, Lane, Thomas R., Major, Michael B., Kuhlman, Brian
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Oxford University Press 2016
Gaiak:
Original Articles
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4678006/
https://ncbi.nlm.nih.gov/pubmed/26489878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/protein/gzv055
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