Engineering a genetically encoded competitive inhibitor of the KEAP1–NRF2 interaction via structure-based design and phage display

In its basal state, KEAP1 binds the transcription factor NRF2 (K(d) = 5 nM) and promotes its degradation by ubiquitylation. Changes in the redox environment lead to modification of key cysteines within KEAP1, resulting in NRF2 protein accumulation and the transcription of genes important for restori...

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Vydáno v:Protein Eng Des Sel
Hlavní autoři: Guntas, Gurkan, Lewis, Steven M., Mulvaney, Kathleen M., Cloer, Erica W., Tripathy, Ashutosh, Lane, Thomas R., Major, Michael B., Kuhlman, Brian
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2016
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Original Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4678006/
https://ncbi.nlm.nih.gov/pubmed/26489878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/protein/gzv055
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