Toll-like receptor 4-mediated inflammation triggered by extracellular IFI16 is enhanced by lipopolysaccharide binding

Damage-associated molecular patterns (DAMPs) are endogenous molecules activating the immune system upon release from injured cells. Here we show that the IFI16 protein, once freely released in the extracellular milieu of chronically inflamed tissues, can function as a DAMP either alone or upon bindi...

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Detalhes bibliográficos
Publicado no:PLoS Pathog
Main Authors: Iannucci, Andrea, Caneparo, Valeria, Raviola, Stefano, Debernardi, Isacco, Colangelo, Donato, Miggiano, Riccardo, Griffante, Gloria, Landolfo, Santo, Gariglio, Marisa, De Andrea, Marco
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2020
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7505474/
https://ncbi.nlm.nih.gov/pubmed/32903274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1008811
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