Toll-like receptor 4-mediated inflammation triggered by extracellular IFI16 is enhanced by lipopolysaccharide binding

Damage-associated molecular patterns (DAMPs) are endogenous molecules activating the immune system upon release from injured cells. Here we show that the IFI16 protein, once freely released in the extracellular milieu of chronically inflamed tissues, can function as a DAMP either alone or upon bindi...

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Vydáno v:PLoS Pathog
Hlavní autoři: Iannucci, Andrea, Caneparo, Valeria, Raviola, Stefano, Debernardi, Isacco, Colangelo, Donato, Miggiano, Riccardo, Griffante, Gloria, Landolfo, Santo, Gariglio, Marisa, De Andrea, Marco
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2020
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7505474/
https://ncbi.nlm.nih.gov/pubmed/32903274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1008811
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