Nuclear DNA Sensor IFI16 as Circulating Protein in Autoimmune Diseases Is a Signal of Damage that Impairs Endothelial Cells through High-Affinity Membrane Binding

IFI16, a nuclear pathogenic DNA sensor induced by several pro-inflammatory cytokines, is a multifaceted protein with various functions. It is also a target for autoantibodies as specific antibodies have been demonstrated in the sera of patients affected by systemic autoimmune diseases. Following tra...

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Main Authors: Gugliesi, Francesca, Bawadekar, Mandar, De Andrea, Marco, Dell’Oste, Valentina, Caneparo, Valeria, Tincani, Angela, Gariglio, Marisa, Landolfo, Santo
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3653904/
https://ncbi.nlm.nih.gov/pubmed/23690979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0063045
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