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The Intracellular DNA Sensor IFI16 Gene Acts as Restriction Factor for Human Cytomegalovirus Replication

Human interferon (IFN)-inducible IFI16 protein, an innate immune sensor of intracellular DNA, modulates various cell functions, however, its role in regulating virus growth remains unresolved. Here, we adopt two approaches to investigate whether IFI16 exerts pro- and/or anti-viral actions. First, th...

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Autors principals: Gariano, Grazia Rosaria, Dell'Oste, Valentina, Bronzini, Matteo, Gatti, Deborah, Luganini, Anna, De Andrea, Marco, Gribaudo, Giorgio, Gariglio, Marisa, Landolfo, Santo
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3266931/
https://ncbi.nlm.nih.gov/pubmed/22291595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1002498
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