Innate Nuclear Sensor IFI16 Translocates into the Cytoplasm during the Early Stage of In Vitro Human Cytomegalovirus Infection and Is Entrapped in the Egressing Virions during the Late Stage

Intrinsic immune mechanisms mediated by constitutively expressed proteins termed “restriction factors” provide frontline antiviral defense. We recently demonstrated that the DNA sensor IFI16 restricts human cytomegalovirus (HCMV) replication by downregulating viral early and late but not immediate-e...

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Detalhes bibliográficos
Main Authors: Dell'Oste, Valentina, Gatti, Deborah, Gugliesi, Francesca, De Andrea, Marco, Bawadekar, Mandar, Lo Cigno, Irene, Biolatti, Matteo, Vallino, Marta, Marschall, Manfred, Gariglio, Marisa, Landolfo, Santo
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
Assuntos:
Virus-Cell Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4054358/
https://ncbi.nlm.nih.gov/pubmed/24696486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00384-14
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