The Extracellular IFI16 Protein Propagates Inflammation in Endothelial Cells Via p38 MAPK and NF-κB p65 Activation

The nuclear interferon-inducible-16 (IFI16) protein acts as DNA sensor in inflammasome signaling and as viral restriction factor. Following Herpesvirus infection or UV-B treatment, IFI16 delocalizes from the nucleus to the cytoplasm and is eventually released into the extracellular milieu. Recently,...

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Detalhes bibliográficos
Publicado no:J Interferon Cytokine Res
Main Authors: Bawadekar, Mandar, De Andrea, Marco, Lo Cigno, Irene, Baldanzi, Gianluca, Caneparo, Valeria, Graziani, Andrea, Landolfo, Santo, Gariglio, Marisa
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2015
Assuntos:
Research Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4490711/
https://ncbi.nlm.nih.gov/pubmed/25715050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/jir.2014.0168
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