Regulatory Interaction between the Cellular Restriction Factor IFI16 and Viral pp65 (pUL83) Modulates Viral Gene Expression and IFI16 Protein Stability

A key player in the intrinsic resistance against human cytomegalovirus (HCMV) is the interferon-γ-inducible protein 16 (IFI16), which behaves as a viral DNA sensor in the first hours postinfection and as a repressor of viral gene transcription in the later stages. Previous studies on HCMV replicatio...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:J Virol
Hauptverfasser: Biolatti, Matteo, Dell'Oste, Valentina, Pautasso, Sara, von Einem, Jens, Marschall, Manfred, Plachter, Bodo, Gariglio, Marisa, De Andrea, Marco, Landolfo, Santo
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2016
Schlagworte:
Virus-Cell Interactions
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5008087/
https://ncbi.nlm.nih.gov/pubmed/27384655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00923-16
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