Human Cytomegalovirus Tegument Protein pp65 (pUL83) Dampens Type I Interferon Production by Inactivating the DNA Sensor cGAS without Affecting STING

The innate immune response plays a pivotal role during human cytomegalovirus (HCMV) primary infection. Indeed, HCMV infection of primary fibroblasts rapidly triggers strong induction of type I interferons (IFN-I), accompanied by proinflammatory cytokine release. Here, we show that primary human fore...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Biolatti, Matteo, Dell'Oste, Valentina, Pautasso, Sara, Gugliesi, Francesca, von Einem, Jens, Krapp, Christian, Jakobsen, Martin Roelsgaard, Borgogna, Cinzia, Gariglio, Marisa, De Andrea, Marco, Landolfo, Santo
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2018
Assuntos:
Virus-Cell Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5827387/
https://ncbi.nlm.nih.gov/pubmed/29263269
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01774-17
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