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Nuclear Targeting of Human Cytomegalovirus Large Tegument Protein pUL48 Is Essential for Viral Growth

We report the identification of a functional nuclear localization signal (NLS) in the human cytomegalovirus (HCMV) large tegument protein pUL48 that is required for nuclear localization in transfected cells and is essential for viral growth. The NLS was mapped to pUL48 amino acid residues 284 to 302...

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Detalhes bibliográficos
Main Authors: Brock, Ivonne, Krüger, Marc, Mertens, Thomas, von Einem, Jens
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3648141/
https://ncbi.nlm.nih.gov/pubmed/23514890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.03558-12
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